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RECORD NUMBER: 128 OF 256

OLS Field Name OLS Field Data
Main Title Initial Submission: Teratology Study of Guar Gum in Rabbits with Attachments and Cover Letter dated 08/03/92.
CORP Author International Research and Development Corp., Mattawan, MI.; Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 88-920004924
Stock Number OTS0542101
Additional Subjects Toxicology ; Health effects ; Guar Gum ; Reproduction/fertility effects ; Teratogenicity ; Mammals ; Rabbits ; Dermal ; Toxic substances ; Laboratory animals ; CAS No 9000-30-0
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NTIS  OTS0542101 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 150p
Abstract
The developmental effects of guar gum (9000-30-0) were evaluated in groups of 20 rabbits by daily dermal administration of the test substance for 6 hours/day at dose levels of 0, 2, 10 and 50 mg/kg/day on days 6 through 18 of gestation. Surviving animals were sacrificed on day 29 of gestation. Mortalities included 2 deaths at 50 mg/kg/day and 1 death at 10 mg/kg/day. A single animal in the control group was sacrificed in extremis. A dose-related increase in dermal irritation (including erythema, edema, and desquamation) was observed in animals receiving 10 and 50 mg/kg/day. The number of early resorptions was significantly increased and the number of viable fetuses was correspondingly decreased at 50 mg/kg/day (p<0.05). The frequency of fetal malformations and variations in the treated groups was comparable to that of the control group at all dose levels. The NOEL was 2 mg/kg/day.