||Initial Submission: Teratology Study of Guar Gum in Rabbits with Attachments and Cover Letter dated 08/03/92.
||International Research and Development Corp., Mattawan, MI.; Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Guar Gum ;
Reproduction/fertility effects ;
Toxic substances ;
Laboratory animals ;
CAS No 9000-30-0
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The developmental effects of guar gum (9000-30-0) were evaluated in groups of 20 rabbits by daily dermal administration of the test substance for 6 hours/day at dose levels of 0, 2, 10 and 50 mg/kg/day on days 6 through 18 of gestation. Surviving animals were sacrificed on day 29 of gestation. Mortalities included 2 deaths at 50 mg/kg/day and 1 death at 10 mg/kg/day. A single animal in the control group was sacrificed in extremis. A dose-related increase in dermal irritation (including erythema, edema, and desquamation) was observed in animals receiving 10 and 50 mg/kg/day. The number of early resorptions was significantly increased and the number of viable fetuses was correspondingly decreased at 50 mg/kg/day (p<0.05). The frequency of fetal malformations and variations in the treated groups was comparable to that of the control group at all dose levels. The NOEL was 2 mg/kg/day.