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RECORD NUMBER: 124 OF 256

OLS Field Name OLS Field Data
Main Title Initial Submission: Teratology Screen in Rats (c-180, C-181, C-182, C-236, C-253, C-254, C-255, C-256, C-257, C-258, C-259) (Final Report) with Attachments and Cover Letter.
CORP Author Hazleton Labs., Falls Church, VA.; Hoechst Celanese Corp., Summit, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1991
Report Number 88-920000177
Stock Number OTS0534627
Additional Subjects Toxicology ; Health effects ; Trimethylolpropane Trimethacrylate ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 3290-92-4
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NTIS  OTS0534627 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 128p
Abstract
Trimethylpropane trimethacrylate (CAS No. 3290-92-4) was evaluated for developmental toxicity. The test material was administered via gavage to 22 CD pregnant rats per group on days 6-15 of gestation at doses of 0 or 2500 mg/kg/day. Significantly lower survival rates and mean body weights were reported for treated dams. An increased incidence of clinical observations included wheezing, dyspnea, urine stains, rough haircoat, hunched posture, bloody crust on the eyes, nose, mouth, and front paws, salivation and alopecia. Lower uterine weights were also observed. An increased number of resorptions and mean incidence of resorptions,and a decreased mean incidence of live fetuses were reported. Significantly decreased fetal body weights (both sexes) and mean fetal length (females) were observed. No skeletal examinations were performed.