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RECORD NUMBER: 121 OF 256

OLS Field Name OLS Field Data
Main Title Initial Submission: Teratologic Evaluation of Inhaled Methyl Ethyl Ketone in Rats (Final Report) with Cover Letter Dated 11/25/1991.
CORP Author Dow Chemical Co., Midland, MI.; Shell Oil Co., Houston, TX.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1991
Report Number 88-920000505
Stock Number OTS0534958
Additional Subjects Toxicology ; Health effects ; Methyl Ethyl Ketone ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 78-93-3
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NTIS  OTS0534958 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 46p
Abstract
Methyl Ethyl Ketone (CAS No. 78-93-3) was evaluated for teratogenicity in groups of 25 (control group of 35) pregnant Sprague-Dawley rats exposed to the test substance by inhalation at concentrations of 0, 400, 1000, or 3000 ppm on 7 hours/day on days 6-15 of gestation. Rats exposed to 3000 ppm showed body weight gain on days 10-15 of gestation and a significant decrease in body weight on day 16. Water consumption was significantly increased on days 10 -15 in rats exposed to 3000 ppm. Rats were sacrificed on day 21 of gestation. The incidence of pregnancy, number of live fetuses per litter and resorptions were not affected at any of the exposure concentrations. The incidence of external, soft tissue alterations or major malformations was not significantly different from controls in any of the treatment groups. Skeletal alterations including an increased incidence of delayed ossification of intraparietal bones of the skull, increased incidence of extra lumbar ribs and delayed ossification of cervical centra were observed at 3000 ppm. There was not an increased incidence of major malformations. Minor skeletal alterations were seen as evidence of a slight fetotoxic effect. The authors concluded that the substance was not embryotoxic or teratogenic at levels up to 3000 ppm.