Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Initial Submission: Summary of Preliminary Information for a Range-Finding Developmental Toxicity Study in Rats of 1,2-Benzenedicarboxylic Acid, Di(asterick) with Cover Letter dated 12/19/1996.
CORP Author Exxon Chemical Americas, Houston, TX.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1996
Report Number 8EHQ-1296-13844
Stock Number OTS0559081
Additional Subjects Toxicology ; Health effects ; Toxic substances ; 1 ; 2-benzenedicarboxylic acid ; DI-C(6-8)-Branched alkyl est(asterick) ; Reproduction ; Fertility effects ; Mammals ; Rats ; Oral ; Gavage ; CAS No 71888-89-6
Library Call Number Additional Info Location Last
NTIS  OTS0559081 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 05/12/2010
Collation 328p
A dose range-finding developmental toxicity study was conducted with 1,2- benzenedicarboxylic acid, di-C6-8-branched alkyl esters, C7 rich (CAS No.71888- 89-6) for the purpose of selecting dose levels for a subsequent definitive study in rats. Because the in-life phase of the range-f inding study was just recently completed, a QA'd report is not yet available. It should be emphasized that because this study was a dose range-finding study, observations should be considered preliminary - a more definitive assessment will require completion of a full developmental toxicity study with a larger number of mated females and more indepth fetal evaluations. The test substance was diluted with corn oil and admmistered by oral gavage to 7 inseminated female rats/group, on gestation days 6-20, at dose levels of 0, 250, 500, 750, and 1000 mg/kg/day. Control animals received corn oil only. All females were sacrificed on gestation day 21 and subjected to Cesarean section. Uteri were removed, weighed, and examined for the number of live fetuses, dead fetuses, and resorptions. Fetuses were sexed, weighed, and examined for external malformations.