Record Display for the EPA National Library Catalog

RECORD NUMBER: 113 OF 256

OLS Field Name OLS Field Data
Main Title Initial Submission: Reproduction Study g 30028 Tech. Rat Seg. Ii (Test for Teratogenic or Embryotoxic Effects) (Final Report) with Cover Letter Dated 01/27/1992.
CORP Author CIBA-GEIGY Corp., Toms River, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 88-920000792
Stock Number OTS0535303
Additional Subjects Toxicology ; Health effects ; Propazine ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 139-40-2
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  OTS0535303 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 34p
Abstract
Propazine (CAS No. 139-40-2) was administered to pregnant Sprague-Dawley rats dosed with 0, 30, 100, 300, or 600 mg/kg/day of body weight by oral gavage on days 6-15 of gestation. At 100 mg/kg/day or above body weight gain and food consumption were decreased (not reported if statistically significant). An increased incidence of abortions was noted at 600 mg/kg/day (not reported if statistically significant). The implantation ratios of the experimental groups were not significantly different from controls. At 300 mg/kg/day or above the average weight of the fetuses was significantly reduced. The only compound-related skeletal effect was the increased unossified calcanei at 300 mg/kg/day or above.