Record Display for the EPA National Library Catalog
RECORD NUMBER: 113 OF 256
|OLS Field Name||OLS Field Data|
|Main Title||Initial Submission: Reproduction Study g 30028 Tech. Rat Seg. Ii (Test for Teratogenic or Embryotoxic Effects) (Final Report) with Cover Letter Dated 01/27/1992.|
|CORP Author||CIBA-GEIGY Corp., Toms River, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; Propazine ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 139-40-2|
Propazine (CAS No. 139-40-2) was administered to pregnant Sprague-Dawley rats dosed with 0, 30, 100, 300, or 600 mg/kg/day of body weight by oral gavage on days 6-15 of gestation. At 100 mg/kg/day or above body weight gain and food consumption were decreased (not reported if statistically significant). An increased incidence of abortions was noted at 600 mg/kg/day (not reported if statistically significant). The implantation ratios of the experimental groups were not significantly different from controls. At 300 mg/kg/day or above the average weight of the fetuses was significantly reduced. The only compound-related skeletal effect was the increased unossified calcanei at 300 mg/kg/day or above.