Record Display for the EPA National Library Catalog
RECORD NUMBER: 110 OF 256
|OLS Field Name||OLS Field Data|
|Main Title||Initial Submission: Report on Cga 18 809 Tech. Teratology Study in Rabbits (Final Report) with Attachments and Cover Letter Dated 01/07/1992.|
|CORP Author||CIBA-GEIGY Corp., Toms River, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; Azamethiphos ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rabbits ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 35575-96-3|
Azamethiphos (CAS No. 35575-96-3) was evaluated for developmental toxicity. Twenty pregnant rabbits (strain was not reported) per group were treated with 0, 2.5, 7.5, or 15 mg/kg/day of the test material by oral gavage on days 6-18 of gestation. Food consumption and body weight gain were reduced in dams at 7.5 and 15 mg/kg/day. At 15 mg/kg/day, significantly decreased body weight, increased numbers of unossified phalangeal nuclei of the fore and hind-limbs, and unossified 5th sternebrae were observed. These observations were related to maternal toxicity. No embryotoxic or teratogenic effects were observed.