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RECORD NUMBER: 103 OF 256

OLS Field Name OLS Field Data
Main Title Initial Submission: Pilot Teratology Study with Decyl Alcohol in Rabbits with Cover Letter dated 08/04/92 and Attachment.
CORP Author International Research and Development Corp., Mattawan, MI.; Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 88-920004887
Stock Number OTS0540964
Additional Subjects Toxicology ; Health effects ; Decyl Alcohol ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rabbits ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 26183-52-8
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NTIS  OTS0540964 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 29p
Abstract
Ethoxylated Decyl Alcohol (CAS No. 26183-52-8) was evaluated to determine the dosage levels for a teratology study. Groups of 5 female New Zealand white rabbits were administered the test substance by gavage at dose levels of 0, 0.12, 0.25, 0.50, 0.75 and 1.00 g/kg/day for 13 days. Mortalities included 1 at 0.12 g/kg, 5 at 0.25 g/kg, 4 at 0.50 g/kg, 4 at 0.75 g/kg, and 5 at 1.00 g/kg. Sixteen of 19 deaths were due to respiratory distress, 2 were due to dosing error (1 each at 0.12 and 0.25 g/kg), and 1 death at 0.75 was due to gastritis. Clonic convulsion were observed at all dose levels (convulsions were more frequent at higher dose levels). Rabbits at 0.50, 0.75 and 1.00 g/kg/day groups displayed tonic convulsions and respiratory distress. There was slight weight loss at 0.50 g/kg/day, moderate weight loss at 0.25, 0.50, and 0.75 g/kg/day, and severe weight loss at 1.00 g/kg/day. Food consumption was statistically decreased at 0.12, 0.25, 0.50, and 0.75 g/kg/day throughout the treatment period and at 1.00 g/kg/day prior to death. The level of significance in all cases was p<0.05.