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OLS Field Name OLS Field Data
Main Title 2-Methyl-2-Aminopropanol Hydrochloride: A Reproduction/Developmental Toxicity Screening Test in CD Rats.
Author E. W. Carney ; J. F. Quast ; C. L. Zablotny
CORP Author Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2005
Report Number 8EHQ-0105-15580B
Stock Number OTS0600001
Additional Subjects 2-Methyl-2-Aminopropanol hydrochloride ; Toxicology ; Health effects ; Reproduction ; Fertility effects ; Reproductive effects ; Mammals ; Rats ; CAS No 124-68-5
Holdings
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NTIS  OTS0600001 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/09/2012
Collation 311p
Abstract
Groups of 12 male and 12 female CD rats were administered 2-methyl-2-aminopropanol hydrochloride (AMP) via the diet at concentrations supplying 0, 100, 300, or 1000 mglkg/day. Female rats were dosed for daily for two weeks prior to breeding, through breeding (two weeks), gestation (three weeks), and through postpartum day 4. Females were necropsied on postpartum day 5. Male rats were dosed two weeks prior to breeding and continuing through breeding (two weeks) until necropsy (test day 38). Effects on reproductive as well as general toxicity were evaluated. In addition, postmortem examinations included a gross necropsy of the adults with collection of organ weights and histopathologic examination of tissues with emphasis on organs of the reproductive system. Litter size, pup survival, sex, body weight, and the presence of gross external abnormalities were also assessed.