Abstract |
Previous investigations have suggested that there is a requirement of dietary polyunsaturated fatty acids for full expression of microsomal enzyme induction. The conclusions in these studies were primarily based on in vitro enzyme activity, sleeping time recovery, or hepatic cytochrome P-450 content, measured 24 hr after treatment with an inducing agent. This study examines the influence of dietary lipids, containing different fatty acid compositions, on the storage and self-induction of lindane metabolism. Depressed food consumption and growth rate, an impaired metabolite excretion pattern, low specific microsomal phospholipid content and a decreased microsomal PC/PE ratio containing a reduced proportion of polyunsaturated fatty acids suggested that a toxic Lindane-DMSO-Dietary lipid interation had occurred. |