||Behavior of Hygroscopic Pharmaceutical Aerosols and the Influence of Hydrophobic Additives.
Hickey, A. J. ;
Martonen., T. B. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Illinois Univ. at Chicago Circle. Dept. of Pharmaceutics.;National Heart, Lung, and Blood Inst., Bethesda, MD.;Science and Engineering Research Council, Swindon (England).
Hygroscopic waters ;
Fatty acids ;
Particle size ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The high temperature and relative humidity in the lung can result in the hygroscopic growth of susceptible aerosol particles or droplets. The term hygroscopic growth describes the increase in particle diameter which occurs as the result of association with water vapor. The influence of hygroscopicity upon lung deposition of aerosols has been a productive area of research in industrial hygiene, environmental sciences, and inhalation toxicology. Many pharmaceutical inhalation aerosols display hygroscopic behavior in their passage through the airways; however, the effect has been neglected. Controlling the phenomenon of hygroscopic growth and, thus, the related lung deposition of aerosols might result in the therapeutic advantage of targeting the site of action. Such an approach might also allow identification of the location of pharmacologic receptor sites in the lung. The review discusses an approach to achieving control of hygroscopic growth of aerosol particles. (Copyright (c) 1993 Plenum Publishing Corporation.)