Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Ethylene Chlorohydrin on Fatty Acid Synthesis.
Author Andrews, J. E. ; Courtney, K. D. ; Donaldson, W. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina State Univ. at Raleigh.
Year Published 1983
Report Number EPA-600/J-83-094;
Stock Number PB84-116300
Additional Subjects Toxicity ; Food contamination ; Environmental surveys ; Fatty acids ; Fumigation ; Synthesis(Chemistry) ; Chickens ; Dosage ; Chlorine organic compounds ; Laboratory animals ; Reprints ; Ethanol/chloro
Library Call Number Additional Info Location Last
NTIS  PB84-116300 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 19p
Male chicks weighing 700 to 900 g. received an acute or eight doses IG of 60 or 40 mg/kg ethylene chlorohydrin (ECH) respectively and were sacrificed eighteen hours after the last dose. Mitochondrial elongation of fatty acids was decreased significantly while fatty acid synthetase activity was not significantly affected by ECH treatment. Cytochrome c oxidase activity in fresh whole liver homogenate was significantly higher in chicks subjected to acute exposure with ECH when compared to the controls. Upon freezing and thawing of homogenates, cytochrome c oxidase activity increased significantly in the control group but was unchanged in the ECH group which suggests that the mitochondrial membrane integrity is compromised by the ECH treatment. Serum and liver triglyceride levels were significantly elevated in both the single and multiple ECH dose groups. Liver to body weight ratios were significantly higher in both treatment groups when compared to their controls. Histological examination of the liver of ECH-treated chicks showed cytoplasmic clearing of the cells but no vacuolization or centrilobular necrosis. Serum isocitrate dehydrogenase levels were significantly higher in the multiple treatment ECH group than in the control group. (Copyright (c) 1983 by Marcel Dekker, Inc.)