Record Display for the EPA National Library Catalog

RECORD NUMBER: 499 OF 954

OLS Field Name OLS Field Data
Main Title Initial Submission: Basic Toxicity of Chloroacetone with Cover Letter dated 09/01/1992.
CORP Author Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-0992-10564
Stock Number OTS0570898
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Chloroacetone ; Subchronic toxicity ; Mammals ; Rats ; Oral ; Gavage ; Primary dermal irritation ; Guinea pigs ; Dermal ; Primary dermal sensitization ; Acute toxicity ; Inhalation ; Mice ; Environmental effects ; Invertebrates ; Freshwater fish ; Mollusks ; Plants ; CAS No 78-95-5
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NTIS  OTS0570898 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 05/27/2010
Collation 12p
Abstract
Groups of five male rats were administered three to thirteen doses of the test compound by gavage at 100, 50, or 10 mg/kg over three to seventeen days. The highest dose severely affected feed intake and body weight gain animals in this group died or were euthanatized after four days. Moderate reductions in feed intake and moderate to severe decreases in body weight gain were also observed at the mid- and low-dose levels. Abnormalities observed in the highdose group included necrotizing gastritis, pale livers, and small seminal vesicals. Histopathologic changes in this group included gastric necrosis, alceration, and perforation. Necrosis of tho liver, spleen, adrenal glands and testis appeared secondary to severe gastric irritation and subsequent peritonitis. Moderate to severe conical atrophy of the thymus was also observed at the highdose level. Histopathologic changes in the mid- and low