Record Display for the EPA National Library Catalog

RECORD NUMBER: 2 OF 2

OLS Field Name OLS Field Data
Main Title Peer consultation workshop on research needs related to the IRIS draft toxicological review of naphthalene : final report.
CORP Author Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment.
Publisher U.S. Environmental Protection Agency, National Center for Environmental Assessment,
Year Published 2005
Report Number EPA/635/R-05/003
Stock Number PB2005-109893
OCLC Number 61446170
Subjects Naphthalene ; Hazardous substances--Health aspects--Reporting
Additional Subjects Toxicology ; Public health ; Naphthalene ; Environmental pollutants ; Pharmacokinetics ; Immune system ; Nervous system ; Teratogens ; Mutagenicity tests ; Carcinogenicity tests ; Biological markers ; Occupational expsoure ; Environmental exposure pathway ; Reproduction(Biology) ; Naphthalene/2-methyl
Internet Access
Description Access URL
https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=90160F00.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EJBD  EPA 635/R-05/003 Headquarters Library/Washington,DC 09/08/2005
NTIS  PB2005-109893 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 04/04/2019
Collation 36 p. ; 28 cm.
Abstract
Naphthalene has been recently characterized as a likely human carcinogen by the U.S. Environmental Protection Agencys (EPA) Integrated Risk Information System (IRIS) Program in a draft Toxicological Review of Naphthalene (U.S. EPA, 2000), based on new information from a two-year inhalation rat bioassay conducted by the National Toxicology Program (NTP, 2000). In the NTP study, positive trend increases in the incidences of two rare nasal tumors, olfactory neuroblastomas in males and females and adenomas of the respiratory epithelium in males, were observed. EPA derived an inhalation unit risk was derived from these findings. The draft assessment was reviewed by an independent external peer review panel in July 2004. Among comments made by the external peer review panel was the desirability of future research to characterize naphthalenes carcinogenic mode of action. To further discuss this comment, EPA decided to sponsor a one-day peer consultation workshop, inviting experts in naphthalene toxicology and chemistry, inhalation toxicology, genetic toxicology, and risk assessment to discuss the specific types of studies that would improve characterization of the mode of action of nasal tumor formation and provide estimates of required research time and resources. The expert opinions and recommendations from this workshop will be considered by EPA in determining a course of action for the development of a scientifically defensible human risk assessment for naphthalene inhalation carcinogenicity.
Notes
"EPA/635/R-05/003." "August 2005." Includes bibliographical references.