Record Display for the EPA National Library Catalog

RECORD NUMBER: 4 OF 12

OLS Field Name OLS Field Data
Main Title Initial Submission: Letter to USEPA Reporting Results of Preliminary Dose Range-Finding Teratology Study in Rabbits with (Confidential Information), dated 11/29/99 (Sanitized).
CORP Author ;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 3 Dec 1999
Year Published 1999
Report Number 8EHQ-1199-14602S;
Stock Number OTS-0559849
Additional Subjects Toxicity ; Teratology ; Dosage ; Dose range-finding ; Rabbits ; Test substances ; Body weight ; Necropsy ; Adverse effects ; Laboratory animals ; Experimental insecticide and miticide
Holdings
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Status
NTIS  OTS-0559849 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 10/08/2007
Collation 11p
Abstract
A contact laboratory has recently completed a preliminary dose range- finding teratology study with non-pregnant Kbl:JW rabbits. Although adverse effects in rats and dogs have previously been reported to the agency, this study presents the first reportable toxicological information on the experimental insecticide and miticide in rabbits was administered in doses of 5ml/kg in a vehicle of a 0.5% aqueous solution of methylcellulose to these rabbits via oral gavage for five days. During these five days, the animals were observed for any effects due to the test substance: clinical signs, food consumption and body weights were monitored daily. Decreased or cessation of defecation and urination were observed in those animals given doses of 100mg and 300mg. Body weights also declined in a animals given these two dose levels. The animals were necropsied on the sixth day. The NOEL was estimated to be 30mg/kg.