||Mutagenic and Carcinogenic Potency of Extracts of Diesel and Related Environmental Emissions: Two-Stage Carcinogenesis in Skin Tumor Sensitive Mice (Sencar).
Slaga, T. J. ;
Triplett, L. L. ;
Nesnow, Stephen ;
||Health Effects Research Lab., Research Triangle Park, NC.;Department of Energy, Washington, DC.
Exhaust gases ;
Laboratory animals ;
Diesel engine exhaust ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Skin tumors can be induced by the sequential application of a subthreshold dose of a carcinogen (initiation phase), followed by repetitive treatment with a noncarcinogenic tumor promoter. There is a very good dose-response relationship between the induction of the number of papillomas per mouse at early times (10 to 20 weeks) by either tumor initiators and promoters and the final carcinoma incidence after a longer latency (20 to 50 weeks) in SENCAR mice. This system not only can be used to determine the tumor initiating and promoting activities of a compound but if the agent is given repeatedly by itself one can also determine if it is a completercarcinogen, i.e., if it has both tumor initiating and promoting activity.