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RECORD NUMBER: 40 OF 68

OLS Field Name OLS Field Data
Main Title Lack of Effect of Low Levels of Carboxyhemoglobin on Cardiovascular Function in Patients with Ischemic Heart Disease (Journal Version).
Author Sheps, D. S. ;
CORP Author North Carolina Univ. at Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1987
Year Published 1987
Report Number EPA/600/J-87/428;
Stock Number PB89-109870
Additional Subjects Carbon monoxide ; Toxicity ; Concentration(Composition) ; Exposure ; Exercise ; Electrocardiography ; Angina pectoris ; Reprints ; Coronary disease ; Carboxyhemoglobin ; Air pollution effects(Human)
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB89-109870 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/14/1989
Collation 11p
Abstract
Thirty patients 38-75 years of age who had ischemic heart disease were studied to assess the effect of acute elevation of carboxyhemoglobin (COHb) concentration. After an initial familiarization and exercise session patients were exposed to air (carboxyhemoglobin (COHb) = 1.5 + 0.05%) and to carbon monoxide (CO) (100 ppm-CIHb-average = 3.8 + 0.1%) on successive days in a double blind, randomized fashion. There was no significant difference in time to onset of angina (air = 312, CO = 306 sec), maximal exercise time (air = 711 sec, CO = 702 sec) maximal ST depression (1.5 min for both), or time to significant ST depression (air = 474 sec, CO = 475 sec). Double product at ST depression and maximal double products were similar for both conditions. Resting ejection fraction was slightly but nonsignificantly higher after CO exposure (air = 53.9%, CO = 55.2%) Maximal ejection fraction was similar for both conditions (air = 57.4%, CO = 57.1%). Change in ejection fraction was slightly lower for CO exposure (air = 3.5%, CO = 2%), p = .049. In conclusion, there is no clinically significant effect of 3.8% COHb (representing a 2.2% increase from resting values) on the cardiovascular system in the study.