Record Display for the EPA National Library Catalog

RECORD NUMBER: 14 OF 18

OLS Field Name OLS Field Data
Main Title Subchronic Inhalation Toxicity Study on Diglyme with Cover Letter dated 05/16/89.
CORP Author Du Pont de Nemours (E.I.) and Co., Wilmington, DE. Haskell Lab. for Toxicology and Industrial Medicine.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 18 May 1981
Year Published 1981
Report Number FYI-OTS-0589-0553;
Stock Number OTS-0000553-2
Additional Subjects Ethers ; Toxicity ; Inhalation ; Exposure ; Concentrations ; Rats ; Laboratory animals ; Testicles ; Histomorphology ; Body weight ; Diethylene glycol dimethyl ether (diglyme) ; Diglyme
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  OTS-0000553-2 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 10/08/2007
Collation 190p
Abstract
In a previous subchronic inhalation toxicity study (HLR 129-88), diethylene glycol dimethyl ether (diglyme) produced testicular injury and degeneration of germinal cells in the epididymides of rats at concentrations of 110, 370 or 1100 ppm. To determine a no-observable-effect level for the testicular injury, 4 groups of 20 male Cr1:CD*BR rats were exposed nose-only, 6 hours/day, 5 days/week for 2 weeks to diglyme at concentrations of 3.1, 9.9, 30, or 98 ppm. A procedural control group of 20 male Crl:CD*BR rats was exposed to air only. After the 10th exposure, 10 rats per group were killed for gross examination. Selected tissues of the male reproductive system were weighed and processed for histomorphologic examination. The remaining rats were killed after a 14-day recovery period and subjected to the same gross and microscopic examinations.