Record Display for the EPA National Library Catalog

RECORD NUMBER: 39 OF 64

OLS Field Name OLS Field Data
Main Title Micronuclei and Other Nuclear Anomalies in Buccal Smears: A Field Test in Snuff Users.
Author Tolbert, P. E. ; Shy, C. M. ; Allen, J. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;North Carolina Univ. at Chapel Hill. School of Public Health.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/445;
Stock Number PB93-141448
Additional Subjects Mouth ; Carcinogenesis ; Tobacco ; Micronucleus tests ; Smokeless tobacco ; Field tests ; Risk factors ; Genetic markers ; Epithelial cells ; Chromosome aberrations ; Public health ; Epidemiologic methods ; Reprints ; Buccal smears ; Snuff
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB93-141448 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/12/1993
Collation 13p
Abstract
A revised protocol for the exfoliated cell micronucleus assay was field-tested in a population exposed to a genotoxic agent at levels associated with a significant increase in cancer risk. The standard assay involves microscope examination of epithelial smears to determine the prevalence of micronucleated cells with separate scoring of other nuclear anomalies associated with cytotoxicity and genotoxicity. Prevalence of micronucleated cells was elevated in the snuff users compared to the non-users. The pattern of relative frequencies of several nuclear anomalies provided strong evidence of a cytotoxic effect of snuff.