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RECORD NUMBER: 36 OF 415

OLS Field Name OLS Field Data
Main Title Biochemical and Morphological Validation of a Rodent Model of Organophosphorus-Induced Delayed Neuropathy.
Author Padilla, S. ; Veronesi, B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1989
Year Published 1989
Report Number EPA/600/D-89/245;
Stock Number PB90-132408
Additional Subjects Toxicology ; Nervous system disorders ; Enzymes ; Esterases ; Rats ; Exposure ; Morphology ; Reprints ; Organophosphorus compounds ; Ataxia
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB90-132408 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/15/1990
Collation 13p
Abstract
The paper describes six years of research designed to validate the use of the rat as a viable alternative to the hen for screening and mechanistic studies of neuropathic OP compounds. To date results indicate that if morphological rather than behavioral endpoints are used, the rat may be a more valid indicator of OPIDN. The rat must be tested with a wider variety of test OPs to substantiate further the NTE/pathology relationship. Over and above the regulatory considerations, it was shown that a familiar laboratory animal, the rat, can be successfully used to address the mechanistic questions of OPIDN and will hopefully be used to unravel those events occurring between OP exposure and the onset of pathological damage.