Record Display for the EPA National Library Catalog

RECORD NUMBER: 89 OF 102

OLS Field Name OLS Field Data
Main Title Summary review of the health effects associated with naphthalene : health issue assessment.
CORP Author United States. Environmental Protection Agency. Environmental Criteria and Assessment Office.
Publisher Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1987
Report Number EPA/600/8-87/055F
Stock Number PB88-172374
OCLC Number 17962455
Additional Subjects Naphthalene ; Environmental health ; Toxicology ; Air pollution ; Emissions ; Exposure ; Humans ; Reviews ; Naphthalene ; Health risks
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=30001GTV.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EJAD  EPA 600/8-87-055F Region 3 Library/Philadelphia, PA 04/12/1996
EJED  EPA-600/8-87-055F OCSPP Chemical Library/Washington,DC 04/28/1995
NTIS  PB88-172374 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation ix, 50 p.
Abstract
Naphthalene is released into ambient air via industrial gaseous and particulate emissions, tobacco use, and through consumer use. The data base concerning exposure of humans via inhalation and associated health effects is virtually nonexistent. Overexposure often results in acute hemolytic anemia and has been associated with cataract formation. There are no available dose-response data. In laboratory animals, two principal target tissues have been identified: non-ciliated bronchiolar epithelial (Clara) cells and eye tissue. The metabolite(s) that is responsible for Clara cell damage is unknown. There are no published studies involving inhalation exposure. Administration of naphthalene by routes other than inhalation has been shown to produce cataracts in rats, rabbits, and one mouse strain. Animal strains with pigmented eyes develop cataracts faster and more severely than albino strains. The likely causative agent is polyphenol oxydase, found only in pigmented eyes, that catalyzes the formation of 1,2-naphthoquione which binds to lens tissue. Negative results have been reported for gene mutations (Salmonella), unscheduled DNA synthesis in rat hepatocytes and microneuclei in mouse bone marrow. Limited teratology studies in rats and rabbits reported no gross abnormalities. In a single dose (300 mg/kg) study in mice, both maternal and fetal toxicity were reported.
Notes
"November 1987." "EPA/600/8-87-055F." Bibliography: p. 39-50.