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RECORD NUMBER: 42 OF 441

OLS Field Name OLS Field Data
Main Title Biomonitoring: An Exposure Science Tool for Exposure and Risk Assessment.
Author C. Tan
CORP Author Environmental Protection Agency, Research Triangle Park, NC. National Exposure Research Lab.
Year Published 2012
Report Number EPA/600/R-12/039; NERL-RTP-HEASD-10-072
Stock Number PB2012-112321
Additional Subjects Biomonitoring ; Exposure ; Science tools ; Risk assessment ; Biomonitoring studies ; Environmental stressors ; Dose levels ; Estimations ; Human health risks ; Biomarkers ; Studies ; Exposure research ; Mathematical models ; Measurements ; Statistical data ; Charts(Graphs) ; Tables(Data) ; National Exposure Research Laboratory(NERL) ; U S Environmental Protection Agency(EPA)
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NTIS  PB2012-112321 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 02/21/2013
Collation 34p
Abstract
Biomonitoring studies of environmental stressors are useful for confirming exposures, estimating dose levels, and evaluating human health risks. However, the complexities of exposure-biomarker and biomarker-response relationships have limited the use of biomarkers in exposure science studies. In this document, an updated source-to-outcome continuum is presented to better define biomarkers as tools for human health research; specific attention is given to biomarker applications in exposure research. This continuum links exposure sources and health outcomes using a compilation of measurements, mathematical models, and model estimates. A tiered approach to biomonitoring analyses is presented, based on this continuum, to categorize the uses of biomonitoring data given various research objectives and the availability of specific measurements and models. Tools that can be used to infer critical model parameters and model estimates (when they are unavailable) also are discussed to improve biomarker utilization for exposure and risk assessments. Finally, frequently encountered complications in biomonitoring studies are discussed, along with suggestions to address these challenges.