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RECORD NUMBER: 215 OF 251

OLS Field Name OLS Field Data
Main Title Status Report: Advances in Inhalation Dosimetry for Gases with Lower Respiratory Tract and Systemic Effects.
Author J. J. Stanek ; E. D. McLanahan
CORP Author Environmental Protection Agency, Research Triangle Park, NC. National Center for Environmental Assessment.
Year Published 2011
Report Number EPA/600/R-11/067
Stock Number PB2012-101459
Additional Subjects Dosimetry ; Inhalation ; Gases ; Respiratory tract ; Children ; Exposure ; Pulmonary blood circulation ; Health effects ; Risk assessment ; Ecological concentration ; Dose response relationships ; Public health
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB2012-101459 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/29/2012
Collation 103p
Abstract
The purpose of this report is to evaluate new scientific developments and advancements in gas dosimetry focusing on tracheobronchial (TB), pulmonary (PU), and systemic/extrarespiratory (ER) inhalation dosimetry related to the U.S. EPA's 1994 Methods for Derivation of Inhalation Reference Concentrations and Applications of Inhalation Dosimetry (U.S. EPA, 1994), hereafter RfC Methods. Particular emphasis is given on animal to human extrapolation and inhalation dosimetry in children. The goal of this project is to provide information necessary for ensuring that methods and guidance used and implemented by EPA in inhalation risk assessment reflects the state-of-the-science. Overall, the scientific advances support and, in some cases, actually build further upon the approaches of the current methodology for gas dosimetry in the tracheobronchial (TB), pulmonary (PU) and extrarespiratory (ER) regions. With regards to gas dosimetry, there appears to be insufficient quantitative evidence to modify the RfC Methods specifically for children; however, in some cases, chemical-specific information may warrant consideration of alternative approaches or adjustments to account for this lifestage. It is anticipated that information will continue to become available to further inform this issue.