Record Display for the EPA National Library Catalog

RECORD NUMBER: 30 OF 594

OLS Field Name OLS Field Data
Main Title Amphetamine-, Scopolamine-, and Caffeine-Induced Locomotor Activity Following 6-Hydroxydopamine Lesions of the Mesolimbic Dopamine System.
Author Joyce, Eileen M. ; Koob, George F. ;
CORP Author Salk Inst., San Diego, CA. Arthur Vining Davis Center for Behavioral Neurobiology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-R-806777; EPA-600/J-81-578;
Stock Number PB82-247990
Additional Subjects Dopamine ; Amphetamines ; Scopolamine ; Caffeine ; Drugs ; Rats ; Laboratory animals ; Toxicity ; Reprints ; Locomotor activity ; Lesions ; Dopamine/hydroxy
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB82-247990 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 5p
Abstract
As previously reported, 6-hydroxydopamine (6-OHDA) lesions to the region of the nucleus accumbens blocked the locomotor activation induced by low doses of d-amphetamine, and produced a supersensitive locomotor response to the dopamine (DA) agonist, apomorphine. This same lesion, however, failed to block the locomotor activation induced by scopolamine of caffeine. These results suggest that scopolamine and caffeine activate locomotion in the rat by acting independently of presynaptic terminals in the mesolimbic DA system.