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RECORD NUMBER: 10 OF 59

OLS Field Name OLS Field Data
Main Title Catecholaminergic-Serotonergic Balance in the CNS and Reproductive Cycling in Aging Rats.
Author Cooper, R. L. ; McNamara, M. C. ; Linnoila, M. ;
CORP Author Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/004;
Stock Number PB86-176088
Additional Subjects Central nervous system ; Reproduction(Biology) ; Drugs ; Toxicology ; Seratonin ; Rats ; Laboratory animals ; Catecholamines ; Age(Biology) ;
Holdings
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Status
NTIS  PB86-176088 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 10p
Abstract
Treatment with the serotonin (5-HT) reuptake inhibitor Zimelidine, 20 mg/kg/24 hrs, s.c., for 14 days increased the duration of vaginal cycles in 3 month-old Long Evans hooded rats. It induced persistent vaginal estrus in 12 or 16 ten-month old animals, and blocked reinitiation of vaginal cycles by L-dopa in 10 of 10 twenty-month old rats. A single injection of zimelidine at 1400 h did not alter the vaginal smear pattern of young or middle-aged cyling females or old constant estrus females. Also, a single dose of zimelidine at 1400 h on the day of vaginal proestrus had no effect on serum LH values in young females. The serotonergic neurotoxin 5,7-hydroxytryptamine, 4 microgram, injected into the ventral and dorsal raphe areas (after desipramine, 25 mg/kg i.p.) reinitiated vaginal cycling in 8 of 13 twenty-month old rats.