Abstract |
To assess interactive toxicity following subacute, concurrent chemical exposure, male Fischer-344 rats, approximately 70 days of age, were given ethanol at 0, 0.05, 0.1, 0.2, or 0.5 ml/kg in corn oil daily by gavage for 14 days (ETOH) group), or the same levels of ethanol with 21 mg of allyl alcohol/kg (ALAC group), or the same levels of ethanol with 20 mg of carbon tetrachloride/kg (CCL4 group). Hepatic response was assessed 24 hr after the last dose. Interactions were evaluated by comparing the ETOH group with either the ALAC group or the CCL4 group using multivariate analysis of variance procedures. No statistically significant interaction was seen between the ETOH group and the ALAC group at the dosages used. |