Section 1. General principles -- What is pharmacology? -- How drugs act. general principles -- How drugs act. molecular aspects -- How drugs act. cellular aspects-excitation, contraction and secretion -- Cell proliferation, apoptosis, repair and regeneration -- Cellular mechanisms. host defence -- Method and measurement in pharmacology -- Drug absorption and distribution 9. Drug metabolism and elimination -- Pharmacokinetics -- Pharmacogenetics, pharmacogenomics and 'personalised medicine' -- Section 2. Chemical mediators -- Chemical mediators and the autonomic nervous system -- Cholinergic transmission -- Noradrenergic transmission -- 5-Hydroxytryptamine and the pharmacology of migraine -- Purines -- Local hormones. cytokines, biologically active lipids, amines and peptides -- Cannabinoids -- Peptides and proteins as mediators -- Nitric oxide -- Section 3. Drugs affecting major organ systems -- The heart -- The vascular system -- Atherosclerosis and lipoprotein metabolism -- Haemostasis and thrombosis -- Haemopoietic system and treatment of anaemia -- Anti-inflammatory and immunosuppressant drugs -- The respiratory system -- The kidney -- The gastrointestinal tract -- The control of blood glucose and drug treatment of diabetes mellitus -- Obesity -- The pituitary and the adrenal cortex -- The thyroid -- The reproductive system -- Bone metabolism -- Section 4. The nervous system -- Chemical transmission and drug action in the central nervous system -- Amino acid transmitters -- Other transmitters and modulators -- Neurodegenerative diseases -- General anaesthetic agents -- Analgesic drugs -- Local anaesthetics and other drugs affecting sodium channels -- Anxiolytic and hypnotic drugs -- Antiepileptic drugs -- Antipsychotic drugs -- Antidepressant drugs -- CNS stimulants and psychotomimetic drugs -- Drug addiction, dependence and abuse -- Section 5. Drugs used for the treatment of infections, cancer and immunological disorders -- Basic principles of antimicrobial chemotherapy -- Antibacterial drugs -- Antiviral drugs -- Antifungal drugs -- Antiprotozoal drugs -- Anthelminthic drugs -- Anticancer drugs -- Section 6. Special topics -- Individual variation and drug interaction -- Harmful effects of drugs -- Lifestyle drugs and drugs in sport -- Biopharmaceuticals and gene therapy -- Drug discovery and development. This edition sets out a clear route through pharmacology for the reader, from a molecular understanding of receptors and drug actions to the clinical use of the most important groups of drugs. It contains everything students need to know about pharmacology in their early years.