Record Display for the EPA National Library Catalog
RECORD NUMBER: 434 OF 4584Main Title | Behavioral Toxicity of Trihalomethane Contaminants of Drinking Water in Mice. | |||||||||||
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Author | Balster, Robert L. ; Borzelleca, Joseph F. ; | |||||||||||
CORP Author | Medical Coll. of Virginia, Richmond. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
Year Published | 1982 | |||||||||||
Report Number | EPA-R-804701; EPA-600/J-81-370; | |||||||||||
Stock Number | PB83-187880 | |||||||||||
Additional Subjects | Toxicology ; Trihalomethane ; Potable water ; Bioassay ; Dosage ; Mice ; Laboratory animals ; Reprints ; Drinking water ; Water pollution effects(Animals) | |||||||||||
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Collation | 12p | |||||||||||
Abstract | The behavioral toxicity of trichloromethane (TCM), dichlorobromomethane (DCBM), dibromochloromethane (DBCM) and tribromonethane (TBM) was evaluated following oral administration in mice. A variety of dosage regimens and behavioral measures were used. Studies included acute dose effect, 14- and 90-day treatments at 300 and 3000 times the estimated average human daily intake of contaminated drinking water, 30 days of 100 mg/kg/day, and 60 days of 100 and 400 mg/kg/day. In addition, TCM was tested for the production of taste aversions with 10-day administration and for behavioral teratology in offspring following extensive perinatal exposure. |