||Improving the Use of Epidemiologic Data in Health Risk Assessment.
Erdreich, L. S. ;
Burnett, C. ;
||Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office. ;National Inst. for Occupational Safety and Health, Cincinnati, OH.
Hazardous materials ;
Health risks ;
Risk assessment ;
Toxic substances ;
Dose-response relationship ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Epidemiolic data with quantitative exposure measures is infrequently available for specific environmental agents. The paper discusses screening and evaluating epidemiologic studies for use in assessing health risk. The approach recognizes that the various designs used to increase statistical power and to control for covariables have different functions in contemporary risk assessment as practiced by regulatory agencies. Each of these study designs is categorized for its role in risk analysis as useful for hazard identification or for dose-response assessment. The numerical level of the exposure data is a deciding factor in using valid epidemiologic studies. However, data measured on an ordinal scale can be used in qualitative assessments and can demonstrate the strength of the relationship. The application of the procedure is illustrated using epidemiologic studies on the carcinogenicity of chemicals contaminated with dioxins.