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OLS Field Name OLS Field Data
Main Title Toxicological Review of Phosgene (CAS No. 75-44-5) in Support of Summary Information on the Integrated Risk Information System (IRIS).
CORP Author Environmental Protection Agency, Washington, DC.
Publisher Dec 2005
Year Published 2005
Report Number EPA/635/R-06/001;
Stock Number PB2006-110282
Additional Subjects Toxicity ; Toxicokinetics ; Hazard identification ; Dose-response assessments ; Humans ; Epidemiology ; Laboratory animals ; Noncancer effects ; Cancer ; Susceptible populations ; Life stages ; Chlorine organic compounds ; Toxic substances ; Phosgene ; Carbon dichloride oxide ; Oral reference dose ; Inhalation reference concentration ; CAS No. 75-44-5
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB2006-110282 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 11/20/2006
Collation 106p
Abstract
This document presents background information and justification for the Integrated Risk Information System (IRIS) Summary of the hazard and dose-response assessment of phosgene. IRIS Summaries may include an oral reference dose (RfD), an inhalation reference concentration (RfC), and a carcinogenicity assessment. The RfD and RfC provide quantitative information for use in risk assessments for health effects known or assumed to be produced through a nonlinear (possibly threshold) mode of action. The RfD (expressed in units of mg/kg-day) is defined as an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. The inhalation RfC (expressed in units of mg/m3) is analogous to the oral RfD, but provides a continuous inhalation exposure estimate. The inhalation RfC considers toxic effects for both the respiratory system (portal-of-entry) and for effects peripheral to the respiratory system (extrarespiratory or systemic effects). This document does not attempt to develop concentration values protective of acute toxicity. For reference purposes, Appendix A presents a summary of the phosgene Acute Exposure Guideline Levels (AEGLs) that was prepared by the National Academy of Sciences.