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RECORD NUMBER: 31 OF 60

OLS Field Name OLS Field Data
Main Title Teratogenic Effects of the Fungicide Dinocap in the Mouse.
Author Rogers, J. M. ; Carver, B. ; Gray, L. E. ; Gray, J. A. ; Kaylock, R. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/371;
Stock Number PB87-198511
Additional Subjects Fungicides ; Teratoma ; Congenital abnormalities ; Mice ; Cleft palate ; Embryos ; Pregnancy ; Reprints ; Dinitrobenzenes ; Teratogens ; Abnormalities drug induced ; Fetal growth retardation ; Dose response relationship drug
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB87-198511 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 9p
Abstract
The teratogenic potential of the fungicide dinocap was evaluated in CD-1 mice. Pregnant mice were dosed by intubation with dinocap in corn oil on gestation days 7-16. Doses used were 0, 5, 10, 20, 40, 80, and 120 mg/kg/day, based on d 6 weight. Dams were killed on d 18, at which time fetuses were counted, weighed, and preserved for necropsy or skeletal examination. The highest dose killed 80% of the dams dosed, while 29% of the dams in the 80 mg/kg group died during dosing. There was no dose-related maternal mortality at lower doses. Net maternal weight gain was affected only at 80 mg/kg/day. There were no live fetuses at 120 mg/kg/day. The number of live fetuses per litter was decreased and resorptions increased at 80 mg/kg. This study shows that dinocap is teratogenic in the CD-1 mouse at doses well below those causing maternal toxicity.