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RECORD NUMBER: 31 OF 34

OLS Field Name OLS Field Data
Main Title Toxicological Review of Dichloromethane (Methylene Chloride) (CAS No. 75-09-2) in Support of Summary Information on the Integrated Risk Information System (IRIS).
CORP Author Environmental Protection Agency, Washington, DC.
Year Published 2011
Report Number EPA/635/R-10/003F
Stock Number PB2012-103598
Additional Subjects Toxicity ; Environmental exposure ; Health hazards ; Dose-response relationships ; Risk assessment ; Toxicology ; Inhalation ; Dichloromethane ; Oral dosage ; Chronic exposure ; Carcinogens ; Bioassay ; Dose rates ; Factor analysis ; Epidemiology ; Chemical properties ; Physical properties ; Dichloromethane(Methylene chloride) ; CAS No 75-09-2 ; Integrated Risk Information System(IRIS)
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NTIS  PB2012-103598 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 07/11/2012
Collation 567p
Abstract
This document presents background information and justification for the Integrated Risk Information System (IRIS) Summary of the hazard and dose-response assessment of dichloromethane. IRIS Summaries may include oral reference dose (RfD) and inhalation reference concentration (RfC) values for chronic and other exposure durations, and a carcinogenicity assessment. The RfD and RfC, if derived, provide quantitative information for use in risk assessments for health effects known or assumed to be produced through a nonlinear (presumed threshold) mode of action. The RfD (expressed in units of mg/kg-day) is defined as an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. The inhalation RfC (expressed in units of mg/m3) is analogous to the oral RfD, but provides a continuous inhalation exposure estimate. The inhalation RfC considers toxic effects for both the respiratory system (portal-of-entry) and for effects peripheral to the respiratory system (extrarespiratory or systemic effects). Reference values are generally derived for chronic exposures (up to a lifetime), but may also be derived for acute (.24 hours), short-term (>24 hours up to 30 days), and subchronic (>30 days up to 10% of lifetime) exposure durations, all of which are derived based on an assumption of continuous exposure throughout the duration specified. Unless specified otherwise, the RfD and RfC are derived for chronic exposure duration. The carcinogenicity assessment provides information on the carcinogenic hazard potential of the substance in question and quantitative estimates of risk from oral and inhalation exposure may be derived. The information includes a weight-of-evidence judgment of the likelihood that the agent is a human carcinogen and the conditions under which the carcinogenic effects may be expressed. Quantitative risk estimates may be derived from the application of a low-dose extrapolation procedure. If derived, the oral slope factor is a plausible upper bound on the estimate of risk per mg/kg-day of oral exposure.