||Non-Toxicity of Urine from Rats Poisoned with 1080.
Gaines, Thomas B. ;
Sumerford, W. T. ;
Hayes, Jr., Wayland J. ;
||Communicable Disease Center, Atlanta, Ga.
Toxic diseases ;
Laboratory animals ;
Experimental data ;
Toxic substances ;
Sodium fluoroacetate ;
Acetic acid/fluoro-(Sodium-salt) ;
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It may be concluded that: (1) The Kruger-Tschirch method or its modifications are not suitable for the detection of 1080 (sodium fluoroacetate) in rat urine, although it is useful for analysis of sodium fluoroacetate in the absence of interfering substances. (2) The addition of rat urine does not interfere with the toxicity to rats of 1081. (3) Rats poisoned by 1080 do not excrete the toxicant or any toxic metabolic proudct in the urine to an extent demonstrable on rats as tested. (4) If any excretion of the toxicant or its end products does occur in the urine, the amount is very small, and the significance of contamination of food or other materials by the urine of 1080-poisoned rats is the same as the significance of contamination by the urine of unpoisoned rats.