Record Display for the EPA National Library Catalog

RECORD NUMBER: 715 OF 1173

OLS Field Name OLS Field Data
Main Title Naphthalene Toxicity in CD-1 Mice: General Toxicology and Immunotoxicology.
Author Shopp, G. M. ; White, K. L. ; Holsapple, M. P. ; Barnes, D. W. ; Duke, S. S. ;
CORP Author Medical Coll. of Virginia, Richmond. Dept. of Pharmacology. ;East Carolina Univ., Greenville, NC. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/159;
Stock Number PB85-146397
Additional Subjects Toxicology ; Environmental surveys ; Laboratory animals ; Exposure ; Metabolism ; Mutagens ; Insecticides ; Dosage ; Reprints ; Naphthalene
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB85-146397 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 18p
Abstract
The purpose of this study was to evaluate the acute and subchronic toxicity, and effects on immune function, of naphthalene (NAP) in random-bred CD-1 mice. The acute oral LD50 of this compound was 533 and 710 mg/kg in male and female mice, respectively. Fourteen- and ninety-day daily oral gavage studies were conducted. A dose of 1/2 the LD50 for 14 days resulted in decreased body weight and decreased spleen and thymus weight in females and males, respectively. Doses of up to 1/4 the LD50 for 90 days resulted in no dose related natalities or decreases in body weight. A dose dependent decrease in aryl hydrocarbon hydroxylase was seen. The immunological parameters assessed (i.e. humoral immunity, cell-mediated immunity, lymphocyte responsiveness and bone marrow function) were not affected in these subchronic studies.