||Naphthalene Toxicity in CD-1 Mice: General Toxicology and Immunotoxicology.
Shopp, G. M. ;
White, K. L. ;
Holsapple, M. P. ;
Barnes, D. W. ;
Duke, S. S. ;
||Medical Coll. of Virginia, Richmond. Dept. of Pharmacology. ;East Carolina Univ., Greenville, NC. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Environmental surveys ;
Laboratory animals ;
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The purpose of this study was to evaluate the acute and subchronic toxicity, and effects on immune function, of naphthalene (NAP) in random-bred CD-1 mice. The acute oral LD50 of this compound was 533 and 710 mg/kg in male and female mice, respectively. Fourteen- and ninety-day daily oral gavage studies were conducted. A dose of 1/2 the LD50 for 14 days resulted in decreased body weight and decreased spleen and thymus weight in females and males, respectively. Doses of up to 1/4 the LD50 for 90 days resulted in no dose related natalities or decreases in body weight. A dose dependent decrease in aryl hydrocarbon hydroxylase was seen. The immunological parameters assessed (i.e. humoral immunity, cell-mediated immunity, lymphocyte responsiveness and bone marrow function) were not affected in these subchronic studies.