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RECORD NUMBER: 714 OF 1173

OLS Field Name OLS Field Data
Main Title Mutagenicity Evaluations of No. A 51 and No. D 202 Glycidyl Acrylate in the Ames Salmonella/Microsome Plate Test. (Final Reports) with Cover Letter dated 01/04/79.
CORP Author Thiokol Corp., Trenton, NJ. ;Litton Bionetics, Inc., Kensington, MD.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 12 Dec 1978
Year Published 1978
Report Number 8EHQ-0179-0270;
Stock Number OTS-0200452
Additional Subjects Toxicity ; Salmonella ; Microsomes ; Mutagenes ; Chemical compounds ; Physiology ; Liver ; Enzymes ; Rats ; In vitro analysis ; Evaluation ; Dosage ; Strains ; Metabolism ; Glycidyl acrylate ; Thiokol Corporation
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NTIS  OTS-0200452 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 07/09/2008
Collation 30p
Abstract
The test compound was examined for mutagenic activity in a series of in vitro microbial assays employing Salmonella indicator organism. The compound was tested directly and in the presence of liver microsomal enzyme preparations from Aroclor-induced rats. The compound was tested over a series of concentrations such that there was either quantitative or qualitative evidence of some chemically-induced physiological effect at the highest dose level. The low dose in all cases was below a concentration that demonstrated any toxic effect. The dose range employed for the evaluation of this compound was from 0.005 ul to 10 ul per plate. The compound was toxic to all the strains at 10 ul per plate. Toxicity was also observed at 5 ul per plate with the strains TA-1535, TA-1537 and TA-1538.