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RECORD NUMBER: 490 OF 1175

OLS Field Name OLS Field Data
Main Title Haloacetonitrile Excretion as Thiocyanate and Inhibition of Dimethylnitrosamine Demethylase: A Proposed Metabolic Scheme.
Author Pereira, M. A. ; Lin, L. H. C. ; Mattox, J. K. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1984
Report Number EPA/600/J-84/344;
Stock Number PB86-118668
Additional Subjects Halogen organic compound ; Water treatment ; Chlorination ; Urine ; Toxicity ; Potable water ; Dosage ; Laboratory animals ; Enzymes ; Carcinogens ; In vitro analysis ; Toxicity ; Inhibitors ; Metabolism ; Thiocyanates ; Bioassay ; Reprints ; Environmental health ; Water pollution effects(Animals) ; Nitrosamine/dimethyl ; Nitrosamine/diethyl ; Acetonitrile/dibromo ; Acetonitrile/dichloro ; Acetonitrile/bromochloro
Holdings
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Status
NTIS  PB86-118668 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 11p
Abstract
Haloacetonitriles, contaminants present in chlorinated drinking water, were administered orally to rats and the urinary excretion of thiocyanate was measured as an index of cyanide release. The urinary excretion of thiocyanate accounted for 14.2% of the dose of monochloroacetonitrile; 7.7 to 12.8% of the dose of bromochloro-, dichloro- and dibromoacetonitrile and 2.25% of the dose of trichloroacetonitrile. The haloacetonitriles inhibited rat liver microsomal dimethylnitrosamine (DMN) demethylase in an in vitro assay system. The relative capacity of the haloacetonitriles to inhibit DMN demethylase and to be excreted as thiocyanate did not correlate.