Record Display for the EPA National Library Catalog
RECORD NUMBER: 489 OF 1173
|OLS Field Name||OLS Field Data|
|Main Title||Guidance for Safety Testing of Baculoviruses.|
|CORP Author||Environmental Protection Agency, Washington, D.C.|
|Stock Number||PB-275 931|
|Additional Subjects||Viruses ; Insect control ; Pest control ; Guidelines ; Exposure ; Safety ; Dosage ; Experimental data ; Skin(Anatomy) ; Toxicity ; Pathology ; Eye(Anatomy) ; Tests ; Respiration ; Tissues(Biology) ; Cultures(Biology) ; Monitors ; Sensitizing ; Animals ; Birds ; Plants(Botany) ; Reprints ; Biological pest control ; Insect viruses|
The following guidance summarizes the data presently required by the Agency to show the safety of nuclear polyhedrosis and granulosis virus insecticides. When testing the safety of insect viruses, primary emphasis must be given to their pathogenicity and not to their toxicity. Pathogenicity is the capability of the microorganism to infect or reproduce, or to cause overt or covert changes, in animals or animal tissue other than target insects. Toxicity means that microorganisms, and/or their by-products, harm the test animal without actual multiplication such as in certain adverse immunological reactions.