Record Display for the EPA National Library Catalog

RECORD NUMBER: 472 OF 1173

OLS Field Name OLS Field Data
Main Title Formation of Benzo(a)pyrene/DNA Adducts and Their Relationship to Tumor Initiation in Mouse Epidermis.
Author Ashurst, S. W. ; Cohen, G. M. ; Nesnow, S. ; DiGiovanni, J. ; Slaga, T. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA/600/J-83/229;
Stock Number PB84-233451
Additional Subjects Toxicology ; Neoplasms ; Laboratory animals ; Aromatic polycyclic hydrocarbons ; Pathology ; Mice ; Skin(Anatomy) ; Dosage ; Reprints ; Benzopyrene
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB84-233451 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 8p
Abstract
The tumorigenicity of benzo(a)pyrene(B(a)P) applied topically as a skin tumor initiator in Sencar mice and the formation of epidermal B(a)P/deoxyribonucleoside adducts were compared over a similar range of doses (50) to 1600 nmol. The tumor initiating activity of B(a)P, its covalent binding to mouse epidermal DNA, and the formation of the major hydrocarbon/deoxyribonucleoside adduct showed approximately parallel dose-response curves.