Record Display for the EPA National Library Catalog

RECORD NUMBER: 465 OF 1175

OLS Field Name OLS Field Data
Main Title Flavor Aversions Induced by Thallium Sulfate: Importance of Route of Administration.
Author Peele, D. B. ; MacPhail, R. C. ; Farmer, J. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/187;
Stock Number PB87-145504
Additional Subjects Toxicology ; Flavor ; Laboratory animals ; Rats ; Dosage ; Reprints ; Thallium sulfate
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB87-145504 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 7p
Abstract
Flavor aversions induced by thallium sulfate: Importance of route of administration. Neurobehavioral Toxicology and Teratology, 00: 00-00, 1985. Flavor aversions induced by intraperitoneal (i.p.) and oral (p.o.) administration of thallium sulfate were compared in a repeated trial, two-bottle preference test. Male Long-Evans rats (N=6/group) were given 30-m access to a 0.1% saccharin solution followed 20-m later by either i.p. or p.o. thallium sulfate (2.5, 5, 10 or 20 mg/kg), vehicle or nothing. Non-treated and vehicle-treated rats consistently preferred the saccharin solution, with relative saccharin intakes ranging from 0.65 to 0.85 over the three choice trials. On the first choice trial, flavor aversions produced by i.p.-administered thallium sulfate were marginal and occurred only at the highest dosage. In contrast, on the first choice trial, p.o.-administered thallium sulfate led to pronounced aversions at all but the lowest dosage. Saccharin preferences on the second and third choice trials resembled those obtained on the first choice trial. These results suggest that failure to obtain toxicant-induced flavor aversions may be due in part to the particular route by which the toxicant is administered.