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RECORD NUMBER: 462 OF 1173

OLS Field Name OLS Field Data
Main Title Fetotoxic Effects of Nickel in Drinking Water in Mice.
Author Berman, Ezra ; Rehnberg, Blair ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Experimental Biology Div.
Year Published 1983
Report Number EPA-600/1-83-007;
Stock Number PB83-225383
Additional Subjects Nickel chloride ; Toxicology ; Pregnancy ; Dosage ; Concentration(Composition) ; Fetotoxity ; Drinking water
Internet Access
Description Access URL
https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=P100R6N9.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB83-225383 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 18p
Abstract
Nickel chloride was administered in drinking water to pregnant mice from the 2nd through the 17th day of gestation at nickel doses of 0, 500, or 1000 ppm. Fetal or maternal toxicity was not seen after administration of 500 ppm of nickel. However, the higher dose caused spontaneous abortions, loss of fetal mass in survivors, and loss of maternal mass. The oral route of administration via drinking water was at least 2.7 times less effective than parenteral routes in producing fetal effects.