Record Display for the EPA National Library Catalog

RECORD NUMBER: 461 OF 1173

OLS Field Name OLS Field Data
Main Title Fetal Toxicity of Toxaphene in Rats and Mice.
Author Chernoff, N. ; Carver., B. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C.
Year Published 1976
Report Number EPA/600/J-76/059;
Stock Number PB-267 873
Additional Subjects Toxicity ; Insecticides ; Pesticides ; Toxicology ; Congenital abnormalities ; Pregnancy ; Body weight ; Brain ; Pathology ; Mortality ; Dosage ; Dose rate ; Lethal dosage ; Sublethal dosage ; Rats ; Mice ; Laboratory animals ; Bioassay ; Terpenes ; Chlorine aliphatic compounds ; Toxaphene ; Fetuses ; Encephalocele ; Reprints
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB-267 873 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 7p
Abstract
Toxaphene administration at dose levels sufficient to cause a high degree of maternal toxicity in the rat resulted in a reduction in fetal weight and a decrease in the degree of skeletal ossification. In the mouse the only significant fetal effect noted was an incidence of encephaloceles. This defect was found only at the highest dose level, one which also resulted in overt maternal toxicity as evidenced by an increased incidence of maternal death and a reduction in weight gain. It thus appears that the administration of toxaphene to rats and mice during the period of embryonic organogenesis results in some fetotoxic effects at levels which cause maternal toxicity.