Record Display for the EPA National Library Catalog
RECORD NUMBER: 460 OF 1175
|OLS Field Name||OLS Field Data|
|Main Title||Fetotoxic Effects of Nickel in Drinking Water in Mice.|
|Author||Berman, Ezra ; Rehnberg, Blair ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC. Experimental Biology Div.|
|Additional Subjects||Nickel chloride ; Toxicology ; Pregnancy ; Dosage ; Concentration(Composition) ; Fetotoxity ; Drinking water|
Nickel chloride was administered in drinking water to pregnant mice from the 2nd through the 17th day of gestation at nickel doses of 0, 500, or 1000 ppm. Fetal or maternal toxicity was not seen after administration of 500 ppm of nickel. However, the higher dose caused spontaneous abortions, loss of fetal mass in survivors, and loss of maternal mass. The oral route of administration via drinking water was at least 2.7 times less effective than parenteral routes in producing fetal effects.