Record Display for the EPA National Library Catalog
RECORD NUMBER: 456 OF 1175
|OLS Field Name||OLS Field Data|
|Main Title||Fate of ingested chrysotile asbestos fiber in the newborn baboon /|
|Author||Hallenbeck, William H. ; Patel-Mandlik, Kusum|
|CORP Author||Illinois Univ. at the Medical Center, Chicago. School of Public Health.;Health Effects Research Lab., Cincinnati, OH.|
|Publisher||Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory ; For sale by the National Technical Information Service,|
|Stock Number||PB-291 686|
|Subjects||Asbestos. ; Serpentine. ; Ingestion.|
|Additional Subjects||Asbestos ; Toxicology ; Bioassay ; Dosage ; Infants ; Primates ; Serpentine ; Diets ; Ingestion(Biology) ; Exposure ; Tables(Data) ; Fibers ; Electron microscopy ; Tissues(Biology) ; Evaluation ; Gastrointestinal system ; Kidney ; Spleen ; Liver ; Pathology ; Potable water ; Baboons ; Drinking water ; Papio anubis ; Water pollution effects(Animals)|
|Collation||viii, 16 pages : illustrations ; 28 cm.|
The objective of this research was to determine if orally administered chrysotile asbestos fibers could penetrate through the gastrointestinal tract of the neonate baboon and be recovered in selected tissues. A neonate baboon was given a cumulative dose of 3 to the 13th power chrysotile fibers per kilogram. At the end of a 9-day feeding period test and control animals were sacrificed. The following tissues were collected: kidney, liver, spleen, heart, lymph nodes, urine, blood, and gastrointestinal tract. Many methodological problems were encountered in preparing tissues for evaluation by electron microscopy. After developing a satisfactory preparation technique, tissue samples of kidney cortex, kidney medulla, spleen, and liver were analyzed. Definitive data are presented which demonstrate the recovery of chrysotile asbestos from kidney cortex tissue. Data concerning the kidney medulla, spleen and liver tissues must be considered preliminary as more definitive work is in progress concerning these and other tissues.
Order no. CA-7-3159-J. Dec. 1978. Includes bibliographical references. Microfiche.