| Main Title |
Formation of Benzo(a)pyrene/DNA Adducts and Their Relationship to Tumor Initiation in Mouse Epidermis. |
| Author |
Ashurst, S. W. ;
Cohen, G. M. ;
Nesnow, S. ;
DiGiovanni, J. ;
Slaga, T. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA/600/J-83/229; |
| Stock Number |
PB84-233451 |
| Additional Subjects |
Toxicology ;
Neoplasms ;
Laboratory animals ;
Aromatic polycyclic hydrocarbons ;
Pathology ;
Mice ;
Skin(Anatomy) ;
Dosage ;
Reprints ;
Benzopyrene
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-233451 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
The tumorigenicity of benzo(a)pyrene(B(a)P) applied topically as a skin tumor initiator in Sencar mice and the formation of epidermal B(a)P/deoxyribonucleoside adducts were compared over a similar range of doses (50) to 1600 nmol. The tumor initiating activity of B(a)P, its covalent binding to mouse epidermal DNA, and the formation of the major hydrocarbon/deoxyribonucleoside adduct showed approximately parallel dose-response curves. |
