||Acute and Subchronic Toxicity of 2,4-Dichlorophenol in DC-1 Mice.
Borzelleca, J. F. ;
Hayes, J. R. ;
Condie, L. W. ;
Egle, J. L. ;
||Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, NC.
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Male and female CD-1 mice were exposed to 2,4-dichlorophenol (DCP) in drinking water containing 10% emulphor for 90 days at concentrations of 0.2, 0.6, and 2.0 mg/ml. The mean daily consumption values ranged from 46.3 to 542 mg/kg/day for females and 34.9 and 419 mg/kg/day in males. In both sexes, water consumption was lower in the emulphor control group than in the water controls. Female mice tended to consume more of the solutions containing DCP than the vehicle control. There were no significant difference in body weight gain between females in the vehicle control and experimental groups. In males the rate of increase was lower in 2 of 14 weeks at the mid-dose and 4 of 14 weeks at the high dose. No differences were found in terminal organ weights or organ weight ratios in either sex. The only hematological differences were an increase in leukocytes at the high dose and an increase in polymorphonuclears at the low dose in males. Clinical chemistry parameters were altered in females only and include a decrease in creatinine (low dose), an increase in BUN/creatinine ratio (mid dose) and an increase in ALP (high dose).