||Comparative Stimulation of gamma HCH Metabolism by Pretreatment of Rats with gamma HCH, DDT, and DDT gama HCH.
Chadwick, R. W. ;
Cranmer, M. F. ;
Peoples., A. J. ;
||Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab.
Laboratory animals ;
Experimental data ;
Chlorine organic compounds ;
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Pretreatment of rats with gamma HCH, DDT, and DDT + gamma HCH accelerates the metabolism of gamma HCH. A single oral dose of 14C - gamma HCH was administered to all animals after a 2-week pretreatment period. The treated rats excreted significantly more radioactivity and stored significantly less 14C - gamma HCH than the control animals. Results of this study suggest that the mechanism by which gamma HCH induces its own degradation differs from the mechanism through which DDT stimulates gamma HCH metabolism.