Record Display for the EPA National Library Catalog

RECORD NUMBER: 193 OF 1173

OLS Field Name OLS Field Data
Main Title Comparative Stimulation of gamma HCH Metabolism by Pretreatment of Rats with gamma HCH, DDT, and DDT + gamma HCH.
Author Chadwick, R. W. ; Cranmer, M. F. ; Peoples., A. J. ;
CORP Author Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Programs.
Year Published 1970
Stock Number PB-275 932
Additional Subjects Pesticides ; DDT ; Insecticides ; Toxicity ; Interactions ; Laboratory animals ; Rats ; Metabolism ; Experimental data ; Chlorine organic compounds ; Dosage ; Excretion ; Labeled substances ; Physiological effects ; Toxicology ; Detoxification ; Cyclohexane/hexachloro ; Toxic substances ; Reprints ; Synergism
Holdings
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Status
NTIS  PB-275 932 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 11p
Abstract
Pretreatment of rats with gamma HCH, DDT, and DDT + gamma HCH accelerates the metabolism of gamma HCH. A single oral dose of 14C gamma HCH was administered to all animals after 2 wk of pretreatment. The treated rats excreted significantly more radioactivity and stored significantly less 14C gamma HCH than the control animals. In addition to significantly larger livers, the treated rats exhibited higher cytochrome P-450 content and greater in vitro enzyme activity than the control animals. The self-induction of gamma HCH metabolism, which has not previously been reported, could be of major importance in establishing a steady-state relationship between exposure and storage of such pesticides by mammals. Both quantitative and qualitative differences in gamma HCH metabolism are observed between the treated groups of rats. DDT pretreatment results in a 35% higher excretion of radioactivity than gamma HCH pretreatment.