Record Display for the EPA National Library Catalog

RECORD NUMBER: 192 OF 1175

OLS Field Name OLS Field Data
Main Title Comparative Study of the Effects of Inhaled Cadmium Chloride and Cadmium Oxide: Pulmonary Response.
Author Grose, E. C. ; Richards, J. H. ; Jaskot, R. H. ; Menache, M. G. ; Graham, J. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. ;North Carolina State Univ. at Raleigh.
Year Published 1987
Report Number EPA/600/J-87/095;
Stock Number PB88-139647
Additional Subjects Toxicology ; Bioassay ; Dosage ; Rats ; Rabbits ; Laboratory animals ; Reprints ; Air pollution effects ; Cadmium chloride ; Cadmium oxide
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB88-139647 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 16p
Abstract
The effect of aerosols of cadmium chloride (CdCl2) and cadmium oxide (CdO) on pulmonary biochemical function were compared. Rats and rabbits were exposed to 0.25, 0.45 or 4.5 mg Cd/cu. m. for 2 hr. Pulmonary toxicity was determined histologically and biochemically. Cadmium chloride and CdO showed a deposition response that was linearly related to the chamber concentration. Both compounds caused multifocal, interstitial pneumonitis 72 hr after exposure, but the CdO lesion was more severe with proliferation of fibrocytic-like cells as well as pneumocytes. Comparing the two Cd compounds at the highest concentration 4.5 mg Cd/cu. m., the biochemical responses in the rat were similar. The majority of the effects occurred 72 hr after exposure with significant increases in: lung weight, lung to body weight ratio, homogenate and supernatant total protein, GSH-reductase, GSH-transferase, and G-6-PDH. However, GSH-peroxidase was inhibited immediately after the CdO exposure.