Record Display for the EPA National Library Catalog

RECORD NUMBER: 178 OF 1173

OLS Field Name OLS Field Data
Main Title Chlorobenzene-Impaired Lindane Metabolism and the Effect of Pretreatment with Chlorobenzene, Lindane, or Chlorobenzene Plus Lindane.
Author Chadwick, R. W. ; Copeland, M. F. ; Froehlich, R. ; Cooke, N. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-600/J-83-208;
Stock Number PB84-205160
Additional Subjects Pesticides ; Toxicology ; Chlorine organic compounds ; Rats ; Laboratory animals ; Dosage ; Reprints ; Lindane ; Cyclohexane/hexachloro ; Chlorobenzene
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB84-205160 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 14p
Abstract
The storage and metabolism of lindane (r-HCH) was studied in the female rat after the administration of a hepatotoxic dose of chlorobenzene. Impaired lindane metabolism was observed following a challenge dose of 1.12g chlorobenzene/kg. The data indicated that a hepatotoxic dose of chlorobenzene (CB) selectively impaired certain pathways, such as dehydrochlorination and the direct hydroxylation of lindane, to a greater extent than others, such as the dehydrogenation and dechlorination of lindane. Pretreatment with a subtoxic level of chlorobenzene produced: (1) significant increases in the dehydrogenation of lindane, (2) significant increase in the excretion of metabolites derived from the dehydrogenation of lindane through hexachlorocylohexene, r-HCCH, (4) significant improvement in the excretion of metabolites derived from CB-impaired dehydrochlorination of lindane as well as from the CB-impaired hydroxylation of lindane, and (5) significant reduction in the level of unaltered lindane stored in the adipose tissue.