Record Display for the EPA National Library Catalog
RECORD NUMBER: 152 OF 1146
|OLS Field Name||OLS Field Data|
|Main Title||Bupropion, d-Amphetamine, and Amitriptyline-Induced Conditioned Taste Aversion in Rats: Dose Effects.|
|Author||Miller, D. B. ; Miller, L. L. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Burroughs Wellcome Co., Research Triangle Park, NC.|
|Additional Subjects||Rats ; Dosage ; Chlorine organic compounds ; Organic sulfates ; Reprints ; Bupropion hydrochloride ; Amphetamine sulfate ; Amitriptyline hydrochloride ; Phenethylamines ; Propanone/(chlorophenyl)-((dimethylethyl)amino)-(hydrochloride) ; CAS 31677-93-7 ; Propanamine/(dihydro-dibenzocycloheptenylidene)-N-N-dimethyl-(hydrochloride) ; CAS 60-13-9 ; CAS 549-18-8|
Nine groups of rats (n+6 per group) were adapted to a daily one-half hour period of water availability. When intake had stabilized, they were allowed access to a 0.1% (w/v) solution of saccharin, and immediately afterward were given IP injections of isotonic saline; bupropion HCl (10.0, 20.0, or 40.0 mg/kg); d-amphetamine-sulfate (0.5, 1.0, 2.0 mg/kg); or amitriptyline HCl (5.0, 10.0, or 20.0 mg/kg); in a volume of 1 ml. The lowest dose of each compound was chosen to be equipotent in screening tests used to identify potential antidepressants. Following 2 days of access to water alone, all groups were given a choice between water and saccharin for 3 consecutive days. All compounds induced taste aversions in a dose-related manner, but amitriptyline induced greater and longer-lasting aversions than either bupropion or d-amphetamine which were equipotent over the dose range studied.